International Abstracts

106 FIBRINOGEN FUNCTION AFTER SEVERE BURN INJURY In order to test the hypothesis that patients with severe burn injury undergo in time fibrinogen function changes, FIBTEM® and fibrinogen concentration were measured simultaneously early after burn trauma. Blood tests were performed immediately and 12, 24, and 48 h after the patients’ admission. Fibrinogen level (Clauss) and four commercially available ROTEM® tests were performed at each time point. In the twenty patients considered, the fibrinogen level and FIBTEM® maximum clot firmness (MCF) were within the reference range until 24 h after burn trauma, but increased significantly after 48 h, and there was a significant correlation between FIBTEM® MCF and fibrinogen level. The results of this prospective observational clinical study therefore show that the fibrinogen function alters soon after burn trauma and that it is possible to visualize this by ROTEM® using the fibrinogen-sensitive FIBTEM® test.